{"id":606,"date":"2026-06-08T02:29:14","date_gmt":"2026-06-08T06:29:14","guid":{"rendered":""},"modified":"2026-06-08T02:29:14","modified_gmt":"2026-06-08T06:29:14","slug":"new-gene-therapies?","status":"publish","type":"post","link":"https:\/\/c2creset.ondigit.us\/?p=606","title":{"rendered":"New Gene Therapies?"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\"><strong><span style=\"color: rgb(0, 102, 153);\">Hox Genes?<\/span><\/strong><br \/>\n<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Certain genes that contain the homeobox sequence, the <span style=\"color: rgb(0, 0, 255);\">hox genes<\/span>, are grouped in sequence along certain chromosomes. The order of this alignment reflects the positions of specific bones and body parts that these genes control. <\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Through the regulatory proteins that they produce, various groups of hox genes orchestrate the entire anatomical structure of the body, including the nervous system. The same genes in a different sequence create a different set of bones and other bodily parts.<br \/>\n<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">GDF11 belongs to the transforming growth factor beta superfamily that controls anterior-posterior patterning by regulating the expression of Hox genes.<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">The precisely set circuits for biological regulation that genes help set in the &quot;older parts&quot; of the brain (brainstem and hypothalamus) comes to the rest of the brains as a more general arrangement of systems and circuitry.<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">This process goes on as a newly born develops and adapts itself when interacting with other individuals and its milieu. The genes that create the fins in fish are the same that create the 4 legs\/arms in land creatures. Just different hox genes for on\/off timing and level or intensity during the growth process. This started about 360 million years ago.<br \/>\n<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Thus there are coding genes that make the body parts (2%), non-coding switch genes that turn the former genes on and off, and non-coding control gene sequences that give the switch genes the orders to go on or off.&nbsp; <\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">The fast majority of differences between the genes of animals vs. humans is in the switch-genes, not the coding genes.<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">The kind of response of the brain stem&#8217;s survival mechanism to each external event, strongly influences the strengthening or weakening of:<\/span><\/span><\/p>\n<ul>\n<li><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">the patterns of connections among neurons, <\/span><\/span><\/li>\n<li><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">their synapses, and thus <\/span><\/span><\/li>\n<li><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">the neural development, resulting in <\/span><\/span><\/li>\n<li><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">the kind of mindset the individual ends up with.<\/span><\/span><\/li>\n<\/ul>\n<p style=\"text-align: center;\"><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" src=\"\/userfiles\/image\/hox-antp%20animation.gif\" width=\"216\" height=\"200\" \/><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: small;\"><span style=\"color: rgb(0, 102, 153);\"><strong><span style=\"font-family: Verdana;\">Gene Therapies<\/span><\/strong><\/span><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">When people lack a certain enzyme because of defects in the gene that makes it, doctors can now inject a harmless virus that permanently implants a healthy working gene, thereby enabling patients to make that enzyme indefinitely.<\/span><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Although still risky, trials have now reported successes against HIV, blood-clotting, and Parkinson&#8217;s disease.<\/span><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">A single fault in DNA then copied into RNA, produces the faulty proteins that underlie some genetic disorders.<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Now biologists have designed &#8216;<span style=\"color: rgb(0, 0, 255);\">genomic debugger<\/span>&#8216; proteins that bind to faulty RNA and fix protein production.&nbsp;<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">The researchers realized that just 2 amino acids within the pattern of this designer protein determine exactly which base of an RNA molecule it will bind to.<\/span><\/span><\/p>\n<p><span style=\"font-size: small;\"><span style=\"font-family: Verdana;\">Recent research results show that seeing specific number sequences will trigger certain genes in the chromosomes of the DNA molecule of certain cells into action or in-action.<\/span><\/span><\/p>\n<p style=\"text-align: right;\"><a href=\"?p=607\"><span style=\"color: rgb(0, 0, 255);\"><span style=\"font-size: x-small;\"><span style=\"font-family: Verdana;\"><strong>read more &#8230;<\/strong><\/span><\/span><\/span><\/a><\/p>\n<p style=\"text-align: right;\">&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hox Genes? Certain genes that contain the homeobox sequence, the hox genes, are grouped in sequence along certain chromosomes. The order of this alignment reflects the positions of specific bones and body parts that these genes control. Through the regulatory proteins that they produce, various groups of hox genes orchestrate the entire anatomical structure of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1623,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/posts\/606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=606"}],"version-history":[{"count":0,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/posts\/606\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=\/wp\/v2\/media\/1623"}],"wp:attachment":[{"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/c2creset.ondigit.us\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}